Showing posts with label Evolution. Show all posts
Showing posts with label Evolution. Show all posts
Greetings everybody

Have you been looking forward to this weeks blog post? I hope you have because I have gathered some awesome facts to see you straight into the weekend. 









That brings us to the end of this weeks post! Have an amazing weekend everybody see you here same time next week. 

Biobunch
Over and out
Greetings everybody

It is that glorious time of the week again - Friday! Interesting week for the UK with the second female Prime Minister accepting her role. Enough about Politics it is the post you all love reading for little bit sized chunks of knowledge. Enjoy guys. 







Some great facts up top, I hope you enjoyed them and that you feel you could use them as a conversation starter... you never know so go and impress someone with some awesome Science facts. 
Have an awesome weekend everybody, 

Biobunch
Over and out
Greetings everybody!

Patience is a virtue and I cannot thank you guys enough for being patient whilst I sorted a few things out. But I am back with some crazy, cool and captivating post ideas for you guys for the next few weeks. What a day to come back Britain is no longer part of the EU and there is a split on whether this is the start of Armageddon or should be celebrated as Independence day, Donald Trump and his family just landed in Scotland Nigel Farage lied about putting more money into the NHS and David Cameron is being a spoilt brat who didn't get his way and has now resigned with Boris Johnson being a potential candidate to be prime minister. 
Yep today, is a day of mixed feelings but you know what i don't have mixed feelings about... blogging for you guys again! Let the good times begin again with Friday Facts and with my renewed subscription to Nature... Enjoy!!







That is all for now folks! I hope you enjoyed some of these weird but crazy facts see you guys same time next week!

Biobunch, 
Over and out

Greetings everybody,

Happy Friday!! As always. Today is a lovely Biology Behind on a not so lovely disease. Everybody has a similar reaction when they hear the C word, that word being cancer, at least we can say that it is not contagious... or is it. Within this post I am going to enlighten or further consolidate your pre-existing knowledge on the Tasmanian devils contagious face cancer! Or in scientific words the Devils Facial Tumor Disease (DFTD).

First of, what is a Tasmanian Devil? Interestingly, it is the largest carnivorous marsupial mammal and is endemic to the Australian Island of Tasmania. Great but what do they look like? Well, get that image of Taz from Looney Tunes out of your minds, because they look very different to that. So different that you will wonder where Taz came from in the first place, take a look.

Just to let you guys know there are a few disturbing pictures in this post

The rise of a contagious cancer:

In 1996 a photographer came across a Tasmanian Devil with a large facial tumour, however, no significant action was taken - after all cancer has been recorded in many animals. Interestingly, that photographer may have seen patient zero for a disease that has now blown through 90% of Tasmania's devil population. 
Devil Facial Tumour Disease is fast approaching to be the first disease to threaten an entire species with extinction. So, how does a cancer such as DFTD spread and kill 90% of a population? Originally, scientists believed this cancer was being triggered through viral infection similar to how the Human Papilloma Virus causes the majority of cervical cancers, this could explain how it spread through the population so fast. As always, nothing is ever so simple and it turned out that the success behind this cancer was far worse.  
Turns out DFTD is one of two confirmed contagious cancers - you read that right contagious! This disease is transmitted through physical transfer of cancerous cells from an infected individual. Devilish behaviour is a key part to this diseases's success, when two Devils meet it is often a violent interaction resulting in a bite. Interestingly, tumours are localised around a Devils face, neck and inside of their mouth- places that receive the most amount of bites. Once bitten, cancerous cells invades the body of its new host, takes root and does what cancer does- proliferate, exponentially. 
After this proliferation period, death soon follows whether it be starvation due to multiple mouth tumours or the tumour diverting nutrient flow to benefit its own growth. 


Passing of cancerous cells from one devil to another fascinated scientists, how can these foreign cells grow inside an unrelated host, why is this not rejected? Tasmanian Devils have a major glitch within their immune systems- well, the part that deals with detecting foreign bodies. Histocompatibility complexes are the most genetically varied structures found in all jawed vertebrate immune systems, the Devil population all have very low levels of genetic variation- as such their ability to recognise foreign bodies is greatly hindered. DFTD took advantage of this glitch and based their entire transmission route around it. 

Darwinian theory and cancer:

It is easy for us to forget that every living cell is seeking out their own optimal growth, their own evolutionary path- so is cancer. DFTD is a contagious cancer, being contagious has allowed this cancer to achieve an evolutionary win. Cancer as we know it, arises from the hosts own cells, proliferates quickly,and evades our bodies immune system because we have trained our immune system to not destroy our cells. Cancer is self destructive and fairly short sighted, by securing its own growth it further kills its host, and there lie every cancers limitation- it is an infinite cell living in a finite host.  Then comes along DFTD an infectious cancer, a cancer able to spread between individuals within a population, allowing them to outlive their original hosts.
Was this an inevitability for cancer? Infinite cancer cells that were only restricted by their finite hosts have cleaved their bonds. Scary! 
In this case it is the basic laws of natural selection that we all know and secretly love for simplicity. 


Evolution 101:
  1. Within a bunch of cancerous cells, some contain a mutation. This mutation allows them to be more virulent, divide faster, acquirer sources better or be passed on to others. 
  2. This new mutation allows these select cells to survive and reproduce
  3. Eventually, cancerous cells with this mutation are now dominating the population. 
There you have it cancer evolves. Necessity is the mother of invention. 

Devils genes and the search for patient 0:

Alright guys, we are going to go diving into a bit of genetics so stick it out with me. In a bid to understand what is going on in this disease scientist took samples from the tumours of several Tasmanian devils as well as a sample from the devils non cancerous tissue. What they found was crazy! 
Alright, so what we know about cancers in humans is that it arises from our own cells right? Yes. But not for the devils cancer, it turned out that the tumours found on the faces of the devils were as genetically different from their host as I am to you guys! 

In summary, the cancers are genetically different from their hosts tissue but are the cancers genetically different from one another?  The answer is- there not. All the cancers that have been sampled from the Devil population are genetically identical! This means the the devils cancer arose from one individual- patient 0. At some point, some of the cells within patient 0 had mutated, these cancer cells contained a majority of Patient 0's DNA, this devil bit another devil and passed on the cancer and eventually it lead to the epidemic we have today. 

Possible ethical debate?

Recently, many species are being threatened with extinction and a lot of these are down to human activities. However, this one is actually not our fault, this one is completely caused by mother nature herself. The devils population has fallen from 140,000 to 20,000 if this trend continues within the next 25-30 years the Devil will be extinct- without intervention. 
Breeding programmes, and recovery populations have been set up for the Devils as there is no practical way of helping those individuals within the wild. A question raised to me by my dad was, should we intervene? 
Here is my train of thought. This is not a human induced extinction. Extinction is a natural phenomenon. History has taught us that when species go extinct this allows for a speciation event to occur, and thus the process continues to go on. Conservation is a massive issue at the moment, but here is the question should we conserve the species (the Tasmanian Devil) or conserve the natural processes (extinction and speciation)? 

Well that was massive question to start of your weekend, let me know what you think. 

Biobunch, 
Over and out


Greetings everybody,



Happy Friday! Todays post will be on  ‘The Battle for the soul of Evolutionary Biology’. Evolutionary Biology is a hot topic in science of late due to an all out war on whether Evolutionary Theory is just fine the way it is (Standard Evolutionary Theory) or if it needs a total reboot in order to fit with modern phenomena (Extended Evolutionary Synthesis). For you guys to form your own opinion, I am going to give you a crash course on what both sides are saying. Enjoy. 


Extended Evolutionary Synthesis (EES): 

IDEOLOGY: 

Extended Evolutionary Synthesis is built on one fundamental idea. Genes cannot take all the credit for evolution. Scientists in support of this idea claim that Standard Evolutionary Theory can cause scientists to have tunnel vision as such they can miss crucial parts of the picture. They argue that the original theory neglects the role processes involved in an organisms growth and development have on their evolution. At present, evolutionary theorists have maxed out on researching an organisms genes and  their phenotypes but have neglected the link between the two. Development.

According to Kevin Laland and his colleagues four phenomena should be integrated into Evolutionary Theory 2.0. Developmental Bias, Niche Construction, Phenotypic Plasticity and Extra Genetic Inheritance. For todays post I will focus on two!

PHENOTYPIC PLASTICITY: 

Now I am not going to go into too much detail about this process because it will be featured in its very own post on Biobunch in the not too distant future. This phenomena describes an organisms ability to reconstruct their developmental path by changing their phenotypic state or activity (e.g. rate of metabolism) in response to novel or varying environmental conditions. 
Below are two examples of this process in action check it out! 






















EXTRA-GENETIC INHERITANCE: 

There is a lot more to inheritance than genes. Extra-Genetic Inheritance takes parent-offspring similarities one step beyond genetics, by explaining the maintenance of behavioural traditions, cultural inheritance and so on. Classic example is the passing of nut cracking knowledge in chimps. 












Closing points: 

Overall, the four phenomena above mentioned may have a far larger explanatory power of why and how evolution occurs than currently given credit for. Overall the synthesis provides an interesting and arguably novel view on evolution by providing more than one route for an organism to ‘fit’ into its environment. 

Scientists that are behind this synthesis, are not completely undermining current evolutionary biology, however, what they are calling for is a wider stance on topics by revamping Standard Evolutionary Theory. After all it has been shown countless times plurality is always the best policy. 

Standard Evolutionary Theory (SET):

IDEOLOGY: 

This is the evolutionary theory that everybody has come across at some stage in life whether it be through the national curriculum, or higher education the point is, it is widely taught to us. This theory was largely formed on the principles set out by ‘The Modern Synthesis’. What is this? Well the great Charles Darwin provided us with natural selection as a process by which evolution is likely to occur. But its missing something, genetics. Thus, ‘The Modern Synthesis’ was born with the union of natural selection with modern age genetics. 
I know that you know this story but take a quick look at the wonderful process Darwin proposed! 



COUNTERARGUMENT:

Scientists in favour of the EES called for a pluralistic approach to be adopted in terms of evolutionary theory. However, this call had been answered long before they asked. Those four phenomena up to this date have been the stars in many papers and many evolutionary biologists would agree that these phenomena are extremely interesting. Indeed, interesting, but not enough to warrant the rebranding of evolutionary theory. 


Never underestimate the power of genes. The discovery of these little hereditary units have allowed for precise predictions and the quantification for many components of evolution! In fact it is thanks to our understanding of genes  as to why we understand one of the biggest scare of the 21st Century- antibiotic resistance.

Now what do we know we need a lot of in the field of science? Evidence. According to those in support of SET, EES are bursting with enthusiasm and optimism but their evidence is not so optimistic. Several of the phenomena have not established a solid link with evolution, whereas the theories in SET (genetic drift, natural selection, mutation and recombination) have been linked as causes of evolution many times over. 



CLOSING POINTS:

Needless to say the concept of an Extended Evolutionary Theory is extremely exciting, and it is likely that the four phenomena listed above will play al large part in the rebranding of the theory in the future. For now, until more studies are done there is no need for such large scale modification. 

It is easy to get the idea that Standard Evolutionary Theory is like the worlds grandfather, set in its ways, unwilling to change and static whereas Extended Evolutionary Synthesis sounds like your bright eyed bushy tailed kid brimming with promise. This is not the case according to scientists Standard Evolutionary Theory has had a brilliant year thanks to many technological advances!

Lastly, ‘Gene-centric’ is not a bad thing! 


Charles Darwin, sorry for the mix up both yourself and your theory are rehired! That brings us to the end of this weeks post, hope you have learnt somethings along the way! Now it is down to you, SET or EES, either way you choose to go, this post has highlighted that this area is growing every day and needs innovative and passionate people! Personally I am interested in the future role phenotypic plasticity may play in an organisms ability to adapt to climate change (the looming threat). 

Until next time guys thats Biobunch

over and out


Greetings everybody, Happy Friday! There are popular misconceptions about evolution, and in order to combat them, this infographic was created. Biobunch has faced these barriers and they have also been documented in literature. The following infographic attempts to clarify five persistent fallacies.





 


Over and out.

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